As a result, SCID foals are highly susceptible to viral, bacterial, fungal and protozoal infections from which they cannot recover. A DNA test is available.Īffected foals do not produce functional B and T lymphocytes, and in turn cannot mount appropriate immune responses to challenges. A mutation in the DNA-dependent protein kinase ( DNA-PK) gene, which codes for an enzyme critical to the development of the immune system and the ability to protect against infections, has been identified in affected individuals. Inherited as an autosomal recessive disorder, SCID has been identified in horses of Arabian and part-Arabian descent. Severe combined immunodeficiency (SCID) is a disease that causes foals to be born with severely weakened immune systems. What is severe combined immunodeficiency?
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